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・ Diffuse extragalactic background radiation
・ Diffuse idiopathic skeletal hyperostosis
・ Diffuse infantile fibromatosis
・ Diffuse infiltrative lymphocytosis syndrome
・ Diffuse Infrared Background Experiment
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・ Diffuse lamellar keratitis
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・ Diffuse leprosy of Lucio and Latapí
・ Diffuse myelinoclastic sclerosis
・ Diffuse neonatal hemangiomatosis
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Diffuse proliferative nephritis
・ Diffuse reflectance infrared fourier transform
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・ Diffuse unilateral subacute neuroretinitis
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Diffuse proliferative nephritis : ウィキペディア英語版
Diffuse proliferative nephritis
Diffuse proliferative nephritis (DPN) or glomerulonephritis (DPGN) is a type of glomerulonephritis that is the most serious form of renal lesions in SLE and is also the most common, occurring in 35% to 60% of patients. Most of the glomeruli show endothelial and mesangial proliferation affecting the entire glomerulus, leading to diffuse hypercellularity of the glomeruli, producing in some cases epithelial crescents that fill Bowman's space. When extensive, immune complexes create an overall thickening of the capillary wall, resembling rigid "wire loops" on routine light microscopy. Electron microscopy reveals electron-dense subendothelial immune complexes (between endothelium and basement membrane). Immune complexes can be visualized by staining with fluorescent antibodies directed against immunoglobulins or complement, resulting in a granular fluorescent staining pattern. In due course, glomerular injury gives rise to scarring (glomerulosclerosis). Most of these patients have hematuria with moderate to severe proteinuria, hypertension, and renal insufficiency.
==References==



抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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